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bioRxiv · 10.1101/2023.03.07.531540

Cellular dynamics under time-varying conditions

Joshi, K.·Roy, S.·Biswas, R. R.·Iyer-Biswas, S.
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Abstract

Building on the known scaling law that a single timescale, a cellular unit of time, governs stochastic growth and division of individual bacterial cells under constant growth conditions, here we propose that a dynamic rescaling of the cellular unit of time serves to capture the dominant effect of changing conditions on the cell age distribution. This temporal scaling ansatz provides a natural representation for these time-dependent dynamics in whose terms the cell age distribution evolves under time-invariant rules! Finally, we discuss relevance of these results to recent high-precision experiments on individual bacterial cells growing and dividing in dynamic environments.

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Joshi, K., Roy, S., Biswas, R. R., Iyer-Biswas, S.. 2023-03-09. Cellular dynamics under time-varying conditions. https://doi.org/10.1101/2023.03.07.531540

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