Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia

Yoshizawa, T.; Miyamura, Y.; Ochi, Y.; Hira, R.; Funahashi, M.; Sakai, Y.; Cui, Y.; Isomura, Y.

doi:10.1101/2023.03.06.531239

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bioRxiv · 10.1101/2023.03.06.531239

Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia

Yoshizawa, T.·Miyamura, Y.·Ochi, Y.·Hira, R.·Funahashi, M.·Sakai, Y.·Cui, Y.·Isomura, Y.

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Abstract

Animals optimize their actions by predicting and verifying their outcomes (e.g., rewards). Reward prediction often requires working memory (WM)-based information. To elucidate the neural basis of WM-based reward prediction, we compared the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) in an alternate reward condition (WM-based) with that in a random (WM-free) reward condition in rats and mice. Positron emission tomography revealed greater VTA activation in the WM-based than the WM-free condition. Lateral and medial VTA neurons displayed differential electrophysiological spike activities reflecting WM-based and WM-free reward prediction error, respectively. Furthermore, phasic DA release in the dorsal and ventral striatum changed as WM-based and WM-free classical conditioning progressed. Consistent with our WM-based model, reward acquisition caused a DA dip only in the dorsal striatum. Thus a dual DA system processes WM-based and WM-free reward prediction in parallel.

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Yoshizawa, T., Miyamura, Y., Ochi, Y., Hira, R., Funahashi, M., Sakai, Y., Cui, Y., Isomura, Y.. 2023-03-06. Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia. https://doi.org/10.1101/2023.03.06.531239

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