Rapid resistance profiling of SARS-CoV-2 protease inhibitors

Moghadasi, S. A.; Biswas, R.; Harki, D. A.; Harris, R.

doi:10.1101/2023.02.25.530000

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bioRxiv · 10.1101/2023.02.25.530000

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

Moghadasi, S. A.·Biswas, R.·Harki, D. A.·Harris, R.

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Abstract

Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms ("fingerprints") and indicate that these next-generation drugs have the potential to be effective against nirmatrelvir-resistant variants and vice versa.

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Moghadasi, S. A., Biswas, R., Harki, D. A., Harris, R.. 2023-02-27. Rapid resistance profiling of SARS-CoV-2 protease inhibitors. https://doi.org/10.1101/2023.02.25.530000

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