Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG

Studenova, A. A.; Forster, C.; Engemann, D. A.; Hensch, T.; Sander, C.; Mauche, N.; Hegerl, U.; Loeffler, M.; Villringer, A.; Nikulin, V. V.

doi:10.1101/2023.02.20.529191

bioRxiv · 10.1101/2023.02.20.529191

Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG

Studenova, A. A.·Forster, C.·Engemann, D. A.·Hensch, T.·Sander, C.·Mauche, N.·Hegerl, U.·Loeffler, M.·Villringer, A.·Nikulin, V. V.

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Abstract

Evoked responses and oscillations represent two major electrophysiological phenomena in the human brain yet the link between them remains rather obscure. Here we show how most frequently studied EEG signals: the P300-evoked response and alpha oscillations (8-12 Hz) can be linked with the baseline-shift mechanism. This mechanism states that oscillations generate evoked responses if oscillations have a non-zero mean and their amplitude is modulated by the stimulus. Therefore, the following predictions should hold: 1) the temporal evolution of P300 and alpha amplitude is similar, 2) spatial localisations of the P300 and alpha amplitude modulation overlap, 3) oscillations are non-zero mean, 4) P300 and alpha amplitude correlate with cognitive scores in a similar fashion. To validate these predictions, we analysed the data set of elderly participants (N=2230, 60-82 years old), using a) resting-state EEG recordings to quantify the mean of oscillations, b) the event-related data, to extract parameters of P300 and alpha rhythm amplitude envelope. We showed that P300 is indeed linked to alpha rhythm, according to all four predictions. Our results provide an unifying view on the interdependency of evoked responses and neuronal oscillations and suggest that P300, at least partly, is generated by the modulation of alpha oscillations.

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Studenova, A. A., Forster, C., Engemann, D. A., Hensch, T., Sander, C., Mauche, N., Hegerl, U., Loeffler, M., Villringer, A., Nikulin, V. V.. 2023-02-21. Event-related modulation of alpha rhythm explains the auditory P300 evoked response in EEG. https://doi.org/10.1101/2023.02.20.529191

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