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bioRxiv · 10.1101/2023.02.19.529160

Dual-wield NTPase: a novel protein family mined from AlphaFold DB

Sakuma, K.·Koike, R.·Ota, M.
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Abstract

AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure of the protein family was surprisingly novel, showing an atypical topology for P-loop NTPases, noticeable two-fold symmetry and two pairs of independent putative active sites. Our findings show that structural data mining is a powerful approach to identifying undiscovered protein families.

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Sakuma, K., Koike, R., Ota, M.. 2023-02-21. Dual-wield NTPase: a novel protein family mined from AlphaFold DB. https://doi.org/10.1101/2023.02.19.529160

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