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bioRxiv · 10.1101/2023.02.17.528908

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

Abstract

Different anatomic locations of the body skin dermis come from different origins, and its positional hereditary information can be maintained in adults, while highly resolvable cellular specialization is less well characterized in different anatomical regions. Pig is regarded as excellent model for human research in view of its similar physiology to human. In this study, we performed single-cell RNA sequencing of six different anatomical skin regions from the Chenghua pig with superior skin thickness trait. We obtained 215,274 cells, representing seven cell types, among which we primarily characterized the heterogeneity of smooth muscle cells, endothelial cells and fibroblasts. We identified several phenotypes of smooth muscle cell and endothelial cell and presented genes expression of pathways such as the immune response in different skin regions. By comparing differentially expressed fibroblast genes among different skin regions, we considered TNN, COL11A1, and INHBA as candidate genes for facilitating ECM accumulation. These findings of heterogeneity in the main three cell types from different anatomic skin sites will contribute to a better understanding of hereditary information and places the potential focus on skin generation, transmission and transplantation, paving the foundation for human skin priming.

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Zou, Q., Yuan, R., Zhang, Y., Wang, Y., Zheng, T., Shi, R., Zhang, M., Li, Y., Fei, K., Feng, R., Pan, B., Zhang, X., Gong, Z., Zhu, L., Tang, G., Li, M., Li, X., Jiang, Y.. 2023-02-18. Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin. https://doi.org/10.1101/2023.02.17.528908

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