Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model

Herate, C.; Marlin, R.; Touret, F.; Bosquet, N. D.; Donati, F.; Relouzat, F.; Junges, L.; Galhaut, M.; Dehan, O.; Sconosciutti, Q.; Nougairede, A.; de Lamballerie, X.; van der Werf, S.; Le Grand, R.

doi:10.1101/2023.02.15.528538

bioRxiv · 10.1101/2023.02.15.528538

Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model

Herate, C.·Marlin, R.·Touret, F.·Bosquet, N. D.·Donati, F.·Relouzat, F.·Junges, L.·Galhaut, M.·Dehan, O.·Sconosciutti, Q.·Nougairede, A.·de Lamballerie, X.·van der Werf, S.·Le Grand, R.

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Abstract

The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19. Recently, both in vitro and in vivo data have suggested that Sotrovimab could retain partial activity against recent omicron sub-lineage such as BA.5 variants, including BQ.1.1. Here we report full efficacy of Sotrovimab against BQ.1.1 viral replication as measure by RT-qPCR in a non-human primate challenge model.

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Herate, C., Marlin, R., Touret, F., Bosquet, N. D., Donati, F., Relouzat, F., Junges, L., Galhaut, M., Dehan, O., Sconosciutti, Q., Nougairede, A., de Lamballerie, X., van der Werf, S., Le Grand, R.. 2023-02-15. Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model. https://doi.org/10.1101/2023.02.15.528538

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