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bioRxiv · 10.1101/2023.02.13.528359

Higher-order co-mutation interactions in mitochondrial genomes

Verma, R. K.·Jalan, S.·Shinde, P.·Mishra, A.
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Abstract

Pair-wise co-mutation networks of the mitochondrial genome have already provided ample evidences about the roles of genetic interactions in the manifestation of phenotype under altered environmental conditions. Here, we present a method to construct and analyze higher-order interactions, namely, 3-uniform hypergraphs of the mitochondrial genome for different altitude populations to decipher the role of co-mutating variable sites beyond pair-wise interactions. While the weights distribution of such gene hyperedges manifested power-law for all the altitudes, we identified altitude-specific genes based on gene hyperedge weight. This framework of hypergraphs serves a promising avenue for future investigation of nuclear genomes in context of phenotypic association and genetic disorders.

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Verma, R. K., Jalan, S., Shinde, P., Mishra, A.. 2023-02-13. Higher-order co-mutation interactions in mitochondrial genomes. https://doi.org/10.1101/2023.02.13.528359

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