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bioRxiv · 10.1101/2023.02.08.527719

Broadband aperiodic components of local field potentials reflect inherent differences between cortical and subcortical activity

Abstract

Information flow in brain networks is reflected in intracerebral local field potential (LFP) measurements that have both periodic and aperiodic components. The 1/f{chi} broadband aperiodic component of the power spectra has been shown to track arousal level and to correlate with other physiological and pathophysiological states, with consistent patterns across cortical regions. Previous studies have focused almost exclusively on cortical neurophysiology. Here we explored the aperiodic activity of subcortical nuclei from the human thalamus and basal ganglia, in relation to simultaneously recorded cortical activity. We elaborated on the FOOOF (fitting of one over f) method by creating a new parameterization of the aperiodic component with independent and more easily interpretable parameters, which allows seamlessly fitting spectra with and without an aperiodic knee, a component of the signal that reflects the dominant timescale of aperiodic fluctuations. First, we found that the aperiodic exponent from sensorimotor cortex in Parkinsons disease (PD) patients correlated with disease severity. Second, although the aperiodic knee frequency changed across cortical regions as previously reported, no aperiodic knee was detected from subcortical regions across movement disorders patients, including the ventral thalamus (VIM), globus pallidus internus (GPi) and subthalamic nucleus (STN). All subcortical region studied exhibited a relatively low aperiodic exponent ({chi}STN=1.3{+/-}0.2, {chi}VIM=1.4{+/-}0.1, {chi}GPi=1.4{+/-}0.1) that differed markedly from cortical values ({chi}Cortex=3.2{+/-}0.4, fkCortex=17{+/-}5 Hz). These differences were replicated in a second dataset from epilepsy patients undergoing intracranial monitoring that included thalamic recordings. The consistently lower aperiodic exponent and lack of an aperiodic knee from all subcortical recordings may reflect cytoarchitectonic and/or functional differences between subcortical nuclei and the cortex. Significance StatementThe broadband aperiodic component of local field potentials is a useful and reproducible index of neural activity. Here we refined a widely used phenomenological model for extracting aperiodic parameters, with which we fit cortical, basal ganglia and thalamic intracranial local field potentials, recorded from unique cohorts of movement disorders and epilepsy patients. We found that the aperiodic exponent in motor cortex is higher in Parkinsons disease patients with more severe motor symptoms, suggesting that aperiodic features may have potential as electrophysiological biomarkers for movement disorders symptoms. Remarkably, we found conspicuous differences in the broadband aperiodic components of basal ganglia and thalamic signals compared to those from neocortex, suggesting that the aperiodic neural timescale of subcortical LFPs is slower than that in cortex.

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BibTeXRIS

Bush, A., Zou, J., Lipski, W. J., Kokkinos, V., Richardson, M.. 2023-02-10. Broadband aperiodic components of local field potentials reflect inherent differences between cortical and subcortical activity. https://doi.org/10.1101/2023.02.08.527719

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