MpoxRadar: a worldwide Mpox genomic surveillance dashboard

Nasri, F.; Wittig, A.; Kongkitimanon, K.; Sanchez Cortes, J.; Brinkmann, A.; Nitsche, A.; Schmachtenberg, A.-J.; Renard, B. Y.; Fuchs, S.

doi:10.1101/2023.02.03.526935

bioRxiv · 10.1101/2023.02.03.526935

MpoxRadar: a worldwide Mpox genomic surveillance dashboard

Nasri, F.·Wittig, A.·Kongkitimanon, K.·Sanchez Cortes, J.·Brinkmann, A.·Nitsche, A.·Schmachtenberg, A.-J.·Renard, B. Y.·Fuchs, S.

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Abstract

Monkeypox (Mpox) is mutating at an exceptional rate for a DNA virus and its global spread is concerning, making genomic surveillance a necessity. With MpoxRadar, we provide an interactive dashboard to track virus variants on mutation level worldwide. MpoxRadar allows users to select among different genomes as reference for comparison. The occurrence of mutation profiles based on the selected reference is indicated on an interactive world map that shows the respective geographic sampling site in customizable time ranges to easily follow the frequency or trend of defined mutations. Furthermore, the user can filter for specific mutations, genes, countries, genome types, and sequencing protocols and download the filtered data directly from MpoxRadar. On the server, we automatically download all Mpox genomes and metadata from the National Center for Biotechnology Information (NCBI) on a daily basis, align them with the different reference genomes, generate mutation profiles, which are stored and linked to the available metainformation in a database. This makes MpoxRadar a practical tool for the genomic survaillance of Mpox, supporting users with limited computational resources. MpoxRadar is open-source and freely accessible at https://MpoxRadar.net. GRAPHICAL ABSTRACT O_FIG_DISPLAY_L [Figure 1] M_FIG_DISPLAY C_FIG_DISPLAY

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Nasri, F., Wittig, A., Kongkitimanon, K., Sanchez Cortes, J., Brinkmann, A., Nitsche, A., Schmachtenberg, A.-J., Renard, B. Y., Fuchs, S.. 2023-02-05. MpoxRadar: a worldwide Mpox genomic surveillance dashboard. https://doi.org/10.1101/2023.02.03.526935

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