The neural activity of auditory conscious perception

Christison-Lagay, K. L.; Freedman, N. C.; Micek, C.; Khalaf, A.; Kronemer, S. I.; Gusso, M. M.; Kim, L.; Forman, S.; Ding, J.; Aksen, M.; Abdel-Aty, A.; Kwon, H.; Markowitz, N.; Yeagle, E.; Espinal, E.; Herrero, J.; Bickel, S.; Young, J.; Mehta, A.; Wu, K.; Gerrard, J.; Damisah, E.; Spencer, D.; Blumenfeld, H.

doi:10.1101/2023.01.12.523829

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bioRxiv · 10.1101/2023.01.12.523829

The neural activity of auditory conscious perception

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Abstract

Although recent work has made significant headway in understanding the temporal and spatial dynamics of the neural mechanisms of conscious perception, much of that work has focused on visual paradigms. To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we developed a task to test within the auditory domain. Participants (n=31) completed an auditory perceptual threshold task while undergoing intracranial electroencephalography (icEEG) for intractable epilepsy. Intracranial recordings from over 2,800 grey matter electrodes representing widespread cortical coverage were analyzed for power in the high gamma range (40-115 Hz)--a frequency range that reflects local neural activity. For trials that were perceived, we find activity in early auditory regions which is accompanied by activity in the right caudal middle frontal gyrus, and shortly thereafter by activity in non-auditory thalamus. This is followed by a wave of activity that sweeps through the higher auditory association regions and into parietal and frontal cortices, similar to the wave observed in our visual conscious perception paradigm. However, for not perceived trials, we find that significant activity is restricted to early auditory regions (and areas immediately adjacent to the Sylvian fissure). These findings show that the broad anatomical regions of cortical and subcortical networks involved in auditory perception are similar to the networks observed with vision, suggesting shared general mechanisms for conscious perception.

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Christison-Lagay, K. L., Freedman, N. C., Micek, C., Khalaf, A., Kronemer, S. I., Gusso, M. M., Kim, L., Forman, S., Ding, J., Aksen, M., Abdel-Aty, A., Kwon, H., Markowitz, N., Yeagle, E., Espinal, E., Herrero, J., Bickel, S., Young, J., Mehta, A., Wu, K., Gerrard, J., Damisah, E., Spencer, D., Blumenfeld, H.. 2023-01-13. The neural activity of auditory conscious perception. https://doi.org/10.1101/2023.01.12.523829

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