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bioRxiv · 10.1101/2023.01.09.523339

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue

Barclay, A. M.·Dhavale, D. D.·Borcik, C. G.·Milchberg, M. H.·Kotzbauer, P. T.·Rienstra, C. M.
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Abstract

Fibrils of the protein -synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.

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Barclay, A. M., Dhavale, D. D., Borcik, C. G., Milchberg, M. H., Kotzbauer, P. T., Rienstra, C. M.. 2023-01-10. 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue. https://doi.org/10.1101/2023.01.09.523339

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