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bioRxiv · 10.1101/2023.01.04.521570

Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex

Abstract

Orbitofrontal cortex (OFC) is classically linked to inhibitory control, emotion regulation and reward processing. Recent perspectives propose that the OFC also generates predictions about perceptual events, actions, and their outcomes. We tested the role of the OFC in detecting violations of prediction at two levels of abstraction (i.e., hierarchical predictive processing) by studying the event-related potentials (ERPs) of patients with focal OFC lesions (n = 12) and healthy controls (n = 14) while they detected deviant sequences of tones in a Local-Global paradigm. The structural regularities of the tones were controlled at two hierarchical levels by rules defined at a local (i.e., between tones within sequences) and at a global (i.e., between sequences) level. In OFC patients, ERPs elicited by standard tones were unaffected at both local and global levels compared to controls. However, patients showed an attenuated mismatch negativity (MMN) and P3a to local prediction violation, as well as a diminished MMN followed by a delayed P3a to the combined local and global level prediction violation. The subsequent P3b component to conditions involving violations of prediction at the level of global rules was preserved in the OFC group. Comparable effects were absent in patients with lesions restricted to the lateral PFC, which lends a degree of anatomical specificity to the altered predictive processing resulting from OFC lesion. Overall, the altered magnitudes and time courses of MMN/P3a responses after lesions to the OFC indicate that the neural correlates of detection of auditory regularity violation is impacted at two hierarchical levels of rule abstraction. HighlightsO_LIOrbitofrontal lesions reduce auditory MMN to unpredicted tones at the local level (between tones within sequences) of the rule hierarchy in the Local-Global paradigm. C_LIO_LIOrbitofrontal lesions also impact combined local and global (between sequences) level auditory deviance response, as manifested by diminished and delayed MMN and delayed P3a. C_LI

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BibTeXRIS

Asko, O., Blenkmann, A. O., Leske, S. L., Foldal, M. D., Llorens, A., Funderud, I., Meling, T., Knight, R. T., Endestad, T., Solbakk, A.-K.. 2023-01-04. Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. https://doi.org/10.1101/2023.01.04.521570

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