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bioRxiv · 10.1101/2022.12.05.519223

BCLncRDB: A comprehensive database of LncRNAs associated with breast cancer

Kumar, S.·Agarwal, A.·Vindal, V.
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Abstract

MotivationBreast cancer, the most common cancer in women, is characterized by high morbidity and mortality worldwide. Recent evidence has shown that long non-coding RNAs (lncRNAs) play a crucial role in the development and progression of breast cancer. Despite this, no database exists primarily for lncRNAs associated with only breast cancer. ResultsWe developed BCLncRDB, a manually curated, comprehensive database of lncRNAs associated with breast cancer. For this, we collected, processed, and analyzed data on breast cancer-associated lncRNAs from different sources, including published literature and TCGA. Currently, our database contains 5,279 unique breast cancer-lncRNA associations. It has the following features: (I) Differentially expressed and methylated lncRNAs, (II) Stage and subtype-specific lncRNAs, and (III) Drugs, Subcellular localization, Sequence, and Chromosome information. Thus, the BCLncRDB provides a dedicated platform for exploring breast cancer-related lncRNAs to advance and support the ongoing research on this disease. Availability and implementationThe database BCLncRDB is publicly available for use at http://sls.uohyd.ac.in/new/bclncrdb. Contactvaibhav@uohyd.ac.in

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Kumar, S., Agarwal, A., Vindal, V.. 2022-12-08. BCLncRDB: A comprehensive database of LncRNAs associated with breast cancer. https://doi.org/10.1101/2022.12.05.519223

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