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bioRxiv · 10.1101/2022.11.29.518334

A Possible Unitary Mechanism for General Anesthesia

Gupta, A.·Sang, Y.·Fontanesi, C.·Turin, L.·Naaman, R.
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Abstract

The oxygen reduction reaction (ORR) is of high importance, among others because of its role in cellular respiration and in the operation of fuel cells. Recently, a possible relation between respiration and general anesthesia has been found. This work aims to explore whether anesthesia related gases affect the ORR. In ORR, oxygen which is in its triplet ground state is reduced to form products that are all in the singlet state. While this process is "in principle" forbidden because of spin conservation, it is known that if the electrons transferred in the ORR are spin polarized, the reaction occurs efficiently. Here we show, in electrochemical experiments, that the efficiency of the oxygen reduction is reduced by the presence of general anesthetics in solution. We suggest that a spin-orbit coupling to the anesthetics depolarizes the spins. This causes both a reduction in reaction efficiency and a change in the reaction products. The findings may point to a possible relation between ORR efficiency and anesthetic action. TOC O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=140 SRC="FIGDIR/small/518334v2_ufig1.gif" ALT="Figure 1"> View larger version (40K): org.highwire.dtl.DTLVardef@4a5b8aorg.highwire.dtl.DTLVardef@1bfc961org.highwire.dtl.DTLVardef@3e002corg.highwire.dtl.DTLVardef@7d74f0_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Gupta, A., Sang, Y., Fontanesi, C., Turin, L., Naaman, R.. 2022-11-30. A Possible Unitary Mechanism for General Anesthesia. https://doi.org/10.1101/2022.11.29.518334

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