DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

Kugler, V.; Lieb, A.; Guerin, N.; Donald, B. R.; Stefan, E.; Kaserer, T.

doi:10.1101/2022.11.02.514903

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bioRxiv · 10.1101/2022.11.02.514903

DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

Kugler, V.·Lieb, A.·Guerin, N.·Donald, B. R.·Stefan, E.·Kaserer, T.

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Abstract

We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyze both protein-protein and protein-DNA interfaces and has been validated on a dataset of clinically relevant mutations. In addition, it was used to predict previously uncharacterized patient mutations in CDK6 and p16 genes, which were experimentally confirmed to impair complex formation.

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Kugler, V., Lieb, A., Guerin, N., Donald, B. R., Stefan, E., Kaserer, T.. 2022-11-03. DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions. https://doi.org/10.1101/2022.11.02.514903

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