Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

Collier, A.-r.; Miller, J.; Hachmann, N.; McMahan, K.; Liu, J.; Bondzie, E.; Gallup, L.; Rowe, M.; Shonberg, E.; Thai, S.; Barrett, J.; Borducchi, E.; Bouffard, E.; Jacob-Dolan, C.; Mazurek, C.; Mutoni, A.; Powers, O.; Sciacca, M.; Surve, N.; VanWyk, H.; Wu, C.; Barouch, D.

doi:10.1101/2022.10.24.513619

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bioRxiv · 10.1101/2022.10.24.513619

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

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Abstract

Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA boosters expressing the Omicron BA.5 and ancestral WA1/2020 Spike proteins have been developed and approved, because BA.5 is currently the dominant SARS-CoV-2 variant and substantially evades neutralizing antibodies (NAbs). Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.

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Collier, A.-r., Miller, J., Hachmann, N., McMahan, K., Liu, J., Bondzie, E., Gallup, L., Rowe, M., Shonberg, E., Thai, S., Barrett, J., Borducchi, E., Bouffard, E., Jacob-Dolan, C., Mazurek, C., Mutoni, A., Powers, O., Sciacca, M., Surve, N., VanWyk, H., Wu, C., Barouch, D.. 2022-10-25. Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters. https://doi.org/10.1101/2022.10.24.513619

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