SGC-CAMKK2-1: A chemical probe for CAMKK2

Wells, C. I.; Liang, Y.; Pulliam, T. L.; Lin, C.; Awad, D.; Eduful, B.; O Byrne, S.; Hossain, M. A.; Catta-Preta, C.; Zonzini Ramos, P.; Gileadi, O.; Gileadi, C.; Counago, R. M.; Stork, B.; Langendorf, C. G.; Nay, K.; Oakhill, J. S.; Mukherjee, D.; Racioppi, L.; Means, A.; York, B.; McDonnell, D. P.; Scott, J. W.; Frigo, D. E.; Drewry, D. H.

doi:10.1101/2022.10.18.512752

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bioRxiv · 10.1101/2022.10.18.512752

SGC-CAMKK2-1: A chemical probe for CAMKK2

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Abstract

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.

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Wells, C. I., Liang, Y., Pulliam, T. L., Lin, C., Awad, D., Eduful, B., O Byrne, S., Hossain, M. A., Catta-Preta, C., Zonzini Ramos, P., Gileadi, O., Gileadi, C., Counago, R. M., Stork, B., Langendorf, C. G., Nay, K., Oakhill, J. S., Mukherjee, D., Racioppi, L., Means, A., York, B., McDonnell, D. P., Scott, J. W., Frigo, D. E., Drewry, D. H.. 2022-10-20. SGC-CAMKK2-1: A chemical probe for CAMKK2. https://doi.org/10.1101/2022.10.18.512752

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