LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma

Zhang, Q.; Yan, L.; Chen, J.; Liu, L.

doi:10.1101/2022.10.09.511516

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bioRxiv · 10.1101/2022.10.09.511516

LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma

Zhang, Q.·Yan, L.·Chen, J.·Liu, L.

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Abstract

The expression and function of LINC01184 in hepatocellular carcinoma are unknown. We analyzed the changes in LINC01184 expression in hepatocellular carcinoma using public data, and also analyzed the relationship between LINC01184 and patient prognosis. In vitro, we investigated the effect of LINC01184 on HCC cell growth using cell activity analysis, clone formation analysis, and regulatory death analysis. We also explored the effect of LINC01184 on HCC cell migration using transwell analysis and scratch assay. We found that LINC01184 was significantly highly expressed in hepatocellular carcinoma tissues. Patients with high LINC01184 levels had poorer overall survival and disease-free survival. knockdown of LINC01184 in HUH7 and PLC/PRF/5 cells inhibited cell proliferation and induced regulatory death. Down-regulation of LINC01184 also leads to a reduction in the migratory capacity of cells. In conclusion, LINC01184 may become a biomarker or a new therapeutic target for HCC.

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Zhang, Q., Yan, L., Chen, J., Liu, L.. 2022-10-11. LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma. https://doi.org/10.1101/2022.10.09.511516

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