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bioRxiv · 10.1101/2022.10.07.511249

Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Lee, S. G.·Kaur, J.·Miao, H.·Kim, W. J.
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Abstract

Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carry out specific functions. Glial GPCRs plays key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. Recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells, but not neurons, disrupts Drosophila development, although knocking down other LGR family members in glia has no impact. Adult-specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.

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Lee, S. G., Kaur, J., Miao, H., Kim, W. J.. 2022-10-07. Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila. https://doi.org/10.1101/2022.10.07.511249

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