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bioRxiv · 10.1101/2022.09.20.508738

Onecut1 partially contributes to liver progenitor cell transition and acquisition of metastatic potential in hepatocellular carcinoma.

Liu, Y.·Higashitsuji, H.·Itoh, K.·Yamaguchi, K.·Umemura, A.·Itoh, Y.·Fujita, J.
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Abstract

Metastasis-initiating cells are considered to originate from stem cell-like cancer cells. In hepatocellular carcinoma, liver progenitor-like cells are reported to be derived from hepatocytes, indicating the possible acquisition of metastatic potential during hepatocyte-to-cholangiocyte transdifferentiation. Consistent with the expression pattern observed during ductal plate formation, we revealed an LPC transition with Onecut1 accumulation both during hepatocyte-to-cholangiocyte transdifferentiation and in a cell model. This event may be associated with transient acquisition of metastatic potential.

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Liu, Y., Higashitsuji, H., Itoh, K., Yamaguchi, K., Umemura, A., Itoh, Y., Fujita, J.. 2022-09-21. Onecut1 partially contributes to liver progenitor cell transition and acquisition of metastatic potential in hepatocellular carcinoma.. https://doi.org/10.1101/2022.09.20.508738

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