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bioRxiv · 10.1101/2022.09.14.507948

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era

Buhler, S.·Calderin, Z.·Bettens, F.·Schaefer, A.·Dantin, C.·Ansari, M.·Mamez, A.-C.·Masouridi-Levrat, S.·Chalandon, Y.·Ferrari-Lacraz, S.·Villard, J.
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Abstract

HLA antigen presentation and T-cell immunity are critical to control viral infection such as SARS-CoV-2. This study performed on samples collected in the pre-COVID-19 era demonstrates that individuals are fully equiped at the genetic level in terms of TCR repertoire and HLA variants to recognize and kill SARS-CoV-2 infected cells. HLA diversity, heterologous immunity and random somatic TCR recombination could explain these observations.

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Buhler, S., Calderin, Z., Bettens, F., Schaefer, A., Dantin, C., Ansari, M., Mamez, A.-C., Masouridi-Levrat, S., Chalandon, Y., Ferrari-Lacraz, S., Villard, J.. 2022-09-14. HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era. https://doi.org/10.1101/2022.09.14.507948

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