A model-free Data-Driven paradigm for in situ patient-specific prediction of human brain response to ultrasound stimulation

Salahshoor, H.; Ortiz, M.

doi:10.1101/2022.09.01.506248

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bioRxiv · 10.1101/2022.09.01.506248

A model-free Data-Driven paradigm for in situ patient-specific prediction of human brain response to ultrasound stimulation

Salahshoor, H.·Ortiz, M.

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Abstract

We present a class of model-free Data-Driven solvers that effectively enable the utilization of in situ and in vivo imaging data directly in full-scale calculations of the mechanical response of the human brain to sonic and ultrasonic stimulation, entirely bypassing the need for analytical modeling or regression of the data. The well-posedness of the approach and its convergence with respect to data are proven analytically. We demonstrate the approach, including its ability to make detailed spatially-resolved patient-specific predictions of wave patterns, using public-domain MRI images, MRE data and commercially available solid-mechanics software.

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Salahshoor, H., Ortiz, M.. 2022-09-03. A model-free Data-Driven paradigm for in situ patient-specific prediction of human brain response to ultrasound stimulation. https://doi.org/10.1101/2022.09.01.506248

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