Arsenic induced alteration of neuroregulatory gene expression in Macrobrachium lamarrei: a neurotoxicological approach to grooming behaviour

Munshi, C.; Mukhuty, A.; Bandyopadhyay, A.; Bhowmik, A. D.; Mondal, P.; Shaw, P.; Bhattacharya, S.

doi:10.1101/2022.08.30.505863

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bioRxiv · 10.1101/2022.08.30.505863

Arsenic induced alteration of neuroregulatory gene expression in Macrobrachium lamarrei: a neurotoxicological approach to grooming behaviour

Munshi, C.·Mukhuty, A.·Bandyopadhyay, A.·Bhowmik, A. D.·Mondal, P.·Shaw, P.·Bhattacharya, S.

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Abstract

Arsenic is a highly active neuromodulator which can induce neurological disorders in invertebrates. The present study is a neurotoxicological approach to assess the toxicity of arsenic trioxide, where grooming behaviour is considered as a behavioural biomarker of arsenic induced stress in the prawns. Non-lethal exposure to arsenic trioxide, manipulates the expression pattern of neuroregulatory marker genes in a freshwater prawn, Macrobrachium lamarrei and induces symptoms of autism spectrum disorders (ASDs) in a short time.

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Munshi, C., Mukhuty, A., Bandyopadhyay, A., Bhowmik, A. D., Mondal, P., Shaw, P., Bhattacharya, S.. 2022-09-01. Arsenic induced alteration of neuroregulatory gene expression in Macrobrachium lamarrei: a neurotoxicological approach to grooming behaviour. https://doi.org/10.1101/2022.08.30.505863

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