Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

Ali, M. K.; Liu, Y.; Wu, J. C.; Perez, V. d. J.; Rhodes, C. J.; Cao, A.; Wilkins, M. R.; Nicolls, M. R.; Spiekerkoetter, E. F.

doi:10.1101/2022.08.27.505495

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bioRxiv · 10.1101/2022.08.27.505495

Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension

Ali, M. K.·Liu, Y.·Wu, J. C.·Perez, V. d. J.·Rhodes, C. J.·Cao, A.·Wilkins, M. R.·Nicolls, M. R.·Spiekerkoetter, E. F.

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Abstract

This study shows that the long non-coding RNA RGMB-AS1 is upregulated in the blood and pulmonary vascular cells of PAH patient and that it regulates BMPR2 signaling. Inhibiting RGMB-AS1 increases BMPR2 signaling and improves pulmonary vascular cell function.

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Ali, M. K., Liu, Y., Wu, J. C., Perez, V. d. J., Rhodes, C. J., Cao, A., Wilkins, M. R., Nicolls, M. R., Spiekerkoetter, E. F.. 2022-08-27. Long non-coding RNA RGMB-AS1 as a novel modulator of Bone Morphogenetic Protein Receptor 2 signaling in pulmonary arterial hypertension. https://doi.org/10.1101/2022.08.27.505495

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