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bioRxiv · 10.1101/2022.08.26.505381

The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions

Abstract

The striatum, input nucleus of the basal ganglia, receives topographically organized input from the cortex and gives rise to the direct and indirect pathways with antagonistic effects on the output of the basal ganglia. We optogenetically stimulated the direct and indirect pathways in mice and measured their influence on perceptual decisions and neuronal activity in the cortex. In a task in which mice had to detect a visual stimulus, unilateral direct-pathway stimulation increased the probability of lick responses to the non-stimulated side and increased cortical activity globally. In contrast, indirect-pathway stimulation increased the probability of licks to the stimulated side and decreased activity in visual cortical areas. To probe the possible role of the two pathways in working memory, we trained the mice to report the location of a stimulus with licking one of two spouts, after a memory delay. Direct-pathway stimulation prior to and during the memory delay enhanced both the neural representation of a contralateral visual stimulus and the number of contraversive choices, whereas indirect-pathway stimulation had the opposite effects, in accordance with an antagonistic influence of the direct and indirect pathways on licking direction. Our results demonstrate how these two pathways influence perceptual decisions and working memories, and modify activity in the cerebral cortex. One sentence summaryVisuomotor transformations are influenced antagonistically by the direct and indirect pathways of the basal ganglia during visual detection and working memory tasks

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BibTeXRIS

van Beest, E. H., Abdelwahab, M. A., Cazemier, J. L., Baltira, C., Maes, M. C., Peri, B. D., Self, M. W., Willuhn, I., Roelfsema, P. R.. 2022-08-26. The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions. https://doi.org/10.1101/2022.08.26.505381

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