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bioRxiv · 10.1101/2022.08.22.504825

Effects of Aging on Cortical Representations of Continuous Speech

Abstract

Understanding speech in a noisy environment is crucial in day-to-day interactions, and yet becomes more challenging with age, even for healthy aging. Age-related changes in the neural mechanisms that enable speech-in-noise listening have been investigated previously; however, the extent to which age affects the timing and fidelity of encoding of target and interfering speech streams are not well understood. Using magnetoencephalography (MEG), we investigated how continuous speech is represented in auditory cortex in the presence of interfering speech, in younger and older adults. Cortical representations were obtained from neural responses that time-locked to the speech envelopes using speech envelope reconstruction and temporal response functions (TRFs). TRFs showed three prominent peaks corresponding to auditory cortical processing stages: early ([~]50 ms), middle ([~]100 ms) and late ([~]200 ms). Older adults showed exaggerated speech envelope representations compared to younger adults. Temporal analysis revealed both that the age-related exaggeration starts as early as [~]50 ms, and that older adults needed a substantially longer integration time window to achieve their better reconstruction of the speech envelope. As expected, with increased speech masking, envelope reconstruction for the attended talker decreased and all three TRF peaks were delayed, with aging contributing additionally to the reduction. Interestingly, for older adults the late peak was delayed, suggesting that this late peak may receive contributions from multiple sources. Together these results suggest that there are several mechanisms at play compensating for age-related temporal processing deficits at several stages, but which are not able to fully reestablish unimpaired speech perception. NEW & NOTEWORTHYWe observed age-related changes in cortical temporal processing of continuous speech that may be related to older adults difficulty understanding speech in noise. These changes occur in both timing and strength of the speech representations at different cortical processing stages, and depend on both noise condition and selective attention. Critically, their dependency on noise condition changes dramatically among the early, middle, and late cortical processing stages, underscoring how aging differentially affects these stages.

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BibTeXRIS

Karunathilake, I. M. D., Dunlap, J. L., Perera, J., Presacco, A., Decruy, L., Anderson, S., Kuchinsky, S. E., Simon, J. Z.. 2022-08-23. Effects of Aging on Cortical Representations of Continuous Speech. https://doi.org/10.1101/2022.08.22.504825

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