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bioRxiv · 10.1101/2022.08.19.504594

3-D structure based prediction of SUMOylation sites

Ramtirtha, Y.·Madhusudhan, M. S.
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Abstract

SUMOylation is a posttranslational modification that involves lysine residues from eukaryotic proteins. Misregulation of the modification has been linked to neuro-degenrative diseases and cancer. All the presently available tools to predict SUMOylation sites are sequence based. Here, we propose a novel structure based prediction tool to discriminate between SUMOylated and non-SUMOylated lysines. We demonstrate the method by carrying out a proof-of-concept study. The method achieved an accuracy of 81% and a Matthews Correlation Coefficient of 0.4.

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Ramtirtha, Y., Madhusudhan, M. S.. 2022-08-22. 3-D structure based prediction of SUMOylation sites. https://doi.org/10.1101/2022.08.19.504594

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