Robustness increases heritability: implications for familial disease

Frank, S. A.

doi:10.1101/2022.08.18.504431

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bioRxiv · 10.1101/2022.08.18.504431

Robustness increases heritability: implications for familial disease

Frank, S. A.

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Abstract

Robustness protects organisms in two ways. Homeostatic buffering lowers the variation of traits caused by internal or external perturbations. Tolerance reduces the consequences of bad situations, such as extreme phenotypes or infections. This article shows that both types of robustness increase the heritability of protected traits. Additionally, robustness strongly increases the heritability of disease. Perhaps the natural tendency for organisms to protect robustly against perturbations partly explains the high heritability that occurs for some diseases.

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Frank, S. A.. 2022-08-18. Robustness increases heritability: implications for familial disease. https://doi.org/10.1101/2022.08.18.504431

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