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bioRxiv · 10.1101/2022.07.31.502232

Cochlear summating potentials to paired-clicks predict speech-in-noise perception and hearing acuity

Lai, J.·Bidelman, G.
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Abstract

Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. Its suspected if relative summating potential (SP) changes are different in CS listeners. In this proof-of-concept study, young, normal-hearing adults were recruited and assigned to a low/high-risk group for having CS based on their audiograms at 9-16 kHz. SPs to paired-clicks with varying inter-click intervals isolated non-refractory receptor components of cochlear activity. Abrupt increases in SPs to paired- vs. single-clicks were observed in high-risk listeners. Critically, overexaggerated SPs predicted speech-in-noise and subjective hearing abilities, suggesting relative SP changes to rapid clicks might help identify putative synaptopathic listeners.

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Lai, J., Bidelman, G.. 2022-08-02. Cochlear summating potentials to paired-clicks predict speech-in-noise perception and hearing acuity. https://doi.org/10.1101/2022.07.31.502232

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