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bioRxiv · 10.1101/2022.07.31.502197

Appetitive and aversive cue reactivities differentiate biotypes of alcohol drinkers

Abstract

Craving reflects the subjective urge to use drugs and can be triggered by both positive and negative emotional states. However, no studies have systematically investigated the relative roles of these mechanisms in the pathophysiology of substance misuse or distinguished the mechanisms in individual vulnerability to substance use disorders. In the current study, we performed meta-analyses of drug cue-elicited reactivity and win and loss processing in the monetary incentive delay task to identify distinct neural correlates of appetitive and aversive responses during cue exposure. We then characterized the appetitive and aversive cue responses in seventy-six alcohol drinkers performing a cue craving task during fMRI. Imaging data were processed according to published routines. The appetitive circuit involved medial cortical regions and the ventral striatum, and the aversive circuit involved the insula, caudate and mid-cingulate cortex. We observed a significant correlation of {beta} estimates of cue-elicited activity of the appetitive and aversive circuit. However, individuals varied in appetitive and aversive cue responses. From the regression of appetitive (y) vs. aversive (x) {beta}, we identified participants in the top 1/3 each of those with positive (n = 15) and negative (n = 11) residuals as "approach" and "avoidance" biotype, with the others as the "mixed" biotype (n = 50). For clinical characteristics, the avoidance biotype showed higher sensitivity to punishment. In contrast, the approach biotype showed higher levels of sensation seeking and alcohol expectancy for social and physical pressure. The findings highlighted distinct neural underpinnings of appetitive and aversive components of cue-elicited reactivity and substantiated the importance of biotyping substance misuse.

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BibTeXRIS

Chen, Y., Li, C.-S. R.. 2022-08-02. Appetitive and aversive cue reactivities differentiate biotypes of alcohol drinkers. https://doi.org/10.1101/2022.07.31.502197

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