OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients

Cassao, G.; Antunes, K. H.; Goncalves, J. I. B.; Santos, L. D.; Abbadi, B. L.; Bizarro, C. V.; Machado, P.; Basso, L. A.; Pasquali, C.; Stein, R.; Souza, A. P. D. d.

doi:10.1101/2022.07.29.502045

bioRxiv · 10.1101/2022.07.29.502045

OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients

Cassao, G.·Antunes, K. H.·Goncalves, J. I. B.·Santos, L. D.·Abbadi, B. L.·Bizarro, C. V.·Machado, P.·Basso, L. A.·Pasquali, C.·Stein, R.·Souza, A. P. D. d.

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Abstract

OM-85 is a bacterial lysate from common respiratory tract pathogens, with an excellent safety profile, widely used to prevent recurrent respiratory tract infections. Several studies have been reporting the antiviral roles of OM-85. Here we demonstrated the effect of ex-vivo OM-85 exposure in nasopharyngeal cells collected from COVID-19 patients. OM-85 decreased the SARS-CoV-2 N1 gene expression and increased RIG-I (DDX58) gene expression in these cells. These data support the antiviral effect of OM-85 against SARS-CoV-2.

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Cassao, G., Antunes, K. H., Goncalves, J. I. B., Santos, L. D., Abbadi, B. L., Bizarro, C. V., Machado, P., Basso, L. A., Pasquali, C., Stein, R., Souza, A. P. D. d.. 2022-07-29. OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients. https://doi.org/10.1101/2022.07.29.502045

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