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bioRxiv · 10.1101/2022.07.26.501562

Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion

Lotter, L. D.·Kohl, S. H.·Gerloff, C.·Bell, L.·Niephaus, A.·Kruppa, J. A.·Dukart, J.·Schulte-Rüther, M.·Reindl, V.·Konrad, K.
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Abstract

Humans synchronize with one another to foster successful interactions. Here, we use a multimodal data fusion approach with the aim of elucidating the neurobiological mechanisms by which interpersonal neural synchronization (INS) occurs. Our meta-analysis of 22 functional magnetic resonance imaging and 69 near-infrared spectroscopy hyperscanning experiments (740 and 3,721 subjects) revealed robust brain-regional correlates of INS in the right temporoparietal junction and left ventral prefrontal cortex. Integrating this meta-analytic information with public databases, biobehavioral and brain-functional association analyses suggested that INS involves sensory-integrative hubs with functional connections to mentalizing and attention networks. On the molecular and genetic levels, we found INS to be associated with GABAergic neurotransmission and layer IV/V neuronal circuits, protracted developmental gene expression patterns, and disorders of neurodevelopment. Although limited by the indirect nature of phenotypic-molecular association analyses, our findings generate new testable hypotheses on the neurobiological basis of INS.

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Lotter, L. D., Kohl, S. H., Gerloff, C., Bell, L., Niephaus, A., Kruppa, J. A., Dukart, J., Schulte-Rüther, M., Reindl, V., Konrad, K.. 2022-07-27. Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion. https://doi.org/10.1101/2022.07.26.501562

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