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bioRxiv · 10.1101/2022.07.26.501544

Connectome spectrum electromagnetic tomography: a method to reconstruct electrical brain sources at high-spatial resolution

Rue Queralt, J.·Fluhr, H.·Tourbier, S.·Aleman Gomez, Y.·Pascucci, D.·Yerly, J.·Glomb, K.·Plomp, G.·Hagmann, P.
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Abstract

Connectome Spectrum Electromagnetic Tomography (CSET) combines diffusion MRI-derived structural connectivity data with well-established graph signal processing tools to solve the M/EEG inverse problem. Using simulated EEG signals from fMRI responses, and two EEG datasets on visual-evoked potentials, we provide evidence supporting that (i) CSET captures realistic neurophysiological patterns with better accuracy than state-of-the-art methods, (ii) CSET can reconstruct brain responses more accurately and with more robustness to intrinsic noise in the EEG signal. These results demonstrate that CSET offers high spatio-temporal accuracy, enabling neuroscientists to extend their research beyond the current limitations of low sampling frequency in functional MRI and the poor spatial resolution of M/EEG.

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Rue Queralt, J., Fluhr, H., Tourbier, S., Aleman Gomez, Y., Pascucci, D., Yerly, J., Glomb, K., Plomp, G., Hagmann, P.. 2022-07-27. Connectome spectrum electromagnetic tomography: a method to reconstruct electrical brain sources at high-spatial resolution. https://doi.org/10.1101/2022.07.26.501544

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