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bioRxiv · 10.1101/2022.07.26.501523

cloneMap: a R package to visualise clonal heterogeneity

Frankell, A.·Colliver, E.·McGranahan, N.·Swanton, C.
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Abstract

Genomic evolution and clonal heterogeneity in the soma are widespread and are involved in various pathologies with devastating consequences to human health, most prominently in neoplasia. Tools to interrogate and visualise the diversity of clonal populations in malignant or non-malignant tissues are currently lacking. cloneMap is a tool to represent clonal heterogeneity in a sample or set of samples, accounting for the clone size and phylogenetic relationships between clones. We apply cloneMap to several publicly available cancer sequencing datasets to demonstrate its ability to provide biological inferences of clonal heterogeneity. cloneMap is an R package available on github (https://github.com/amf71/cloneMap).

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Frankell, A., Colliver, E., McGranahan, N., Swanton, C.. 2022-07-27. cloneMap: a R package to visualise clonal heterogeneity. https://doi.org/10.1101/2022.07.26.501523

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