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bioRxiv · 10.1101/2022.07.19.500625

Low amplitude transcutaneous auricular vagus nerve stimulation modulates performance but not pupil size during non-native speech category learning

Abstract

Sub-threshold transcutaneous auricular vagus nerve stimulation (taVNS) synchronized with behavioral training can selectively enhance non-native speech category learning in adults. Prior work has demonstrated behavioral performance increases when taVNS is paired with easier-to-learn Mandarin tone categories in native English listeners, relative to when taVNS is paired with harder-to-learn Mandarin tone categories or without taVNS. Mechanistically, this temporally-precise plasticity has been attributed to noradrenergic modulation. However, prior work did not specifically utilize methodologies that indexed noradrenergic modulation and, therefore, were unable to explicitly test this hypothesis. Our goals for the current study were to use pupillometry to gain mechanistic insights into taVNS behavioral effects. Participants learned to categorize Mandarin tones while pupillometry was recorded. In a double-blind design, participants were divided into two taVNS groups that, as in the prior study, differed according to whether taVNS was paired with easier-to-learn tones or harder-to-learn tones. We found that taVNS led to faster rates of learning on trials paired with stimulation. Lower amplitude taVNS also led to faster rates of learning compared to higher amplitude taVNS. However, these effects were not group specific, and we did not find evidence of a taVNS correlate in the pupillary response. The results suggest that stimulation amplitude may be a critical determinant of learning outcomes and pupillary modulation. Future studies on subthreshold taVNS need to systematically evaluate the effect of stimulation intensity on behavioral plasticity and potential taVNS biomarkers.

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BibTeXRIS

McHaney, J. R., Schuerman, W. L., Leonard, M. K., Chandresekaran, B.. 2022-07-20. Low amplitude transcutaneous auricular vagus nerve stimulation modulates performance but not pupil size during non-native speech category learning. https://doi.org/10.1101/2022.07.19.500625

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