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bioRxiv · 10.1101/2022.07.15.500187

Illuminating the Druggable Genome through Patent Bioactivity Data

Leach, A. R.·Magarinos, M. P.·Gaulton, A.·Felix, E.·Kiziloren, T.·Arcila, R.·Oprea, T. I.
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Abstract

The patent literature is a potentially valuable source of bioactivity data. The SureChEMBL database (https://www.surechembl.org/) is a publicly available large-scale resource that contains compounds extracted on a daily basis from the full text, images and attachments of patent documents, through an automated text and image-mining pipeline. In this paper we describe a process to prioritise 3.7 million life science relevant patents obtained from SureChEMBL, according to how likely they were to contain bioactivity data for potent small molecules on less-studied targets, according to the classification developed by the Illuminating the Druggable Genome (IDG) project. The overall goal was to select a smaller number of patents that could be manually curated and incorporated into the ChEMBL database. We describe the approach taken, the results obtained, and provide some illustrative examples.

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Leach, A. R., Magarinos, M. P., Gaulton, A., Felix, E., Kiziloren, T., Arcila, R., Oprea, T. I.. 2022-07-18. Illuminating the Druggable Genome through Patent Bioactivity Data. https://doi.org/10.1101/2022.07.15.500187

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