Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques

Ma, Z.-M.; Olstad, K. J.; Van Rompay, K. K. A.; Iyer, S. S.; Miller, C. J.; Reader, J. R.

doi:10.1101/2022.07.12.499813

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bioRxiv · 10.1101/2022.07.12.499813

Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques

Ma, Z.-M.·Olstad, K. J.·Van Rompay, K. K. A.·Iyer, S. S.·Miller, C. J.·Reader, J. R.

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Abstract

Pulmonary immunity against SARS-CoV-2 infection has not been well studied. This study investigated the distribution of immune cells int the lungs of 8 rhesus macaques experimentally infected with SARS-CoV-2, and euthanized 11-14 days later. Using immunohistochemistry, inducible bronchus-associated lymphoid tissue was found in all animals. The inducible bronchus-associated lymphoid tissues were composed of B cells, T cells, and follicular dendritic cells with evidence of lymphocyte priming and differentiation. This suggests local immunity plays an important role in the SARS-CoV-2 infection. Further study of local immunity in the lung would benefit our understanding of SARS-CoV-2 pathogenesis and could lead to new interventions to control the SARS-CoV-2 infection and disease.

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Ma, Z.-M., Olstad, K. J., Van Rompay, K. K. A., Iyer, S. S., Miller, C. J., Reader, J. R.. 2022-07-13. Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques. https://doi.org/10.1101/2022.07.12.499813

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