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bioRxiv · 10.1101/2022.07.12.499695

Dual-stream cortical feedbacks mediate sensory prediction

Chu, Q.·Ma, O.·Hang, Y.·Tian, X.
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Abstract

Predictions are constantly generated from diverse sources to optimize cognitive functions in the ever-changing environment. However, the neural origin and generation process of top-down induced prediction remain elusive. We hypothesized that motor-based and memory-based predictions are mediated by distinct feedback networks from motor and memory systems to the sensory cortices. Using fMRI and a dual imagery paradigm, we showed that motor and memory upstream systems excited the auditory cortex in a content-specific manner. Moreover, the inferior and posterior parts of the parietal lobe differentially relayed predictive signals in motor-to-sensory and memory-to-sensory networks. Our results reveal the functionally distinct neural networks that mediate top-down sensory prediction and ground the neurocomputational basis of predictive processing.

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Chu, Q., Ma, O., Hang, Y., Tian, X.. 2022-07-15. Dual-stream cortical feedbacks mediate sensory prediction. https://doi.org/10.1101/2022.07.12.499695

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