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bioRxiv · 10.1101/2022.07.10.499483

Frameshifts may carry oncogenic potential beyond loss of function and categorize genes role in tumor development

Kirov, S.
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Abstract

In this work I present evidence that frameshift mutations represent substantial oncogenic potential across multiple tumor types and may change our understanding of the function of some genes with well established tumor suppressor. I analyzed data deposited in Cbio portal and show that frameshifts, even when they result in the removal of a substantial part of a protein have the potential to create recurring large domains with unknown function. Based on this analysis I propose a novel categorization of genes according to their association with cancer that is more reflective of a complex nature that goes beyond the simple division to tumor suppressors and oncogenes.

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Kirov, S.. 2022-07-12. Frameshifts may carry oncogenic potential beyond loss of function and categorize genes role in tumor development. https://doi.org/10.1101/2022.07.10.499483

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