Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Sullivan, J. R.; Yao, J.; Courtine, C.; Lupien, A.; Herrmann, J.; Müller, R.; Behr, M. A.

doi:10.1101/2022.06.27.497873

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bioRxiv · 10.1101/2022.06.27.497873

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Sullivan, J. R.·Yao, J.·Courtine, C.·Lupien, A.·Herrmann, J.·Müller, R.·Behr, M. A.

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Abstract

The prevalence of lung disease caused by Mycobacterium abscessus is increasing among patients with cystic fibrosis. M. abscessus is a multidrug resistant opportunistic pathogen that is notoriously difficult to treat due to a lack of efficacious therapeutic regimens. Currently, there are no standard regimens, and treatment guidelines are based empirically on drug susceptibility testing. Thus, novel antibiotics are required. Natural products represent a vast pool of biologically active compounds that have a history of being a good source of antibiotics. Here, we screened a library of 517 natural products purified from fermentations of various bacteria and fungi against M. abscessus ATCC 19977. Lysobactin and sorangicin A were active against the M. abscessus complex and drug resistant clinical isolates. These natural products merit further consideration to be included in the M. abscessus drug pipeline.

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Sullivan, J. R., Yao, J., Courtine, C., Lupien, A., Herrmann, J., Müller, R., Behr, M. A.. 2022-06-29. Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex. https://doi.org/10.1101/2022.06.27.497873

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