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bioRxiv · 10.1101/2022.06.24.497456

Deep brain cancer metastasis detection with wide-volume Raman spectroscopy through a single tapered fiber

Pisano, F.·Masmudi Martin, M.·Andriani, M. S.·Cid, E.·Pisanello, M.·Balena, A.·Collard, L. J.·Tantussi, F.·Grande, M.·Sileo, L.·Gentile, F.·De Angelis, F.·De Vittorio, M.·de la Prida, L. M.·Valiente, M.·Pisanello, F.
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Abstract

We propose a low-invasive method to enable implantable, large volume Raman spectroscopy in arbitrarily deep brain regions of the mouse brain. Using a single tapered fiber as thin as 1 m at the tip, we identified diagnostic markers of brain metastasis - the most frequent brain tumor in human adults - with overall accuracy [≥] 90%. We view our approach as a promising complement to the existing palette of tools for optical interrogation of the brain.

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Pisano, F., Masmudi Martin, M., Andriani, M. S., Cid, E., Pisanello, M., Balena, A., Collard, L. J., Tantussi, F., Grande, M., Sileo, L., Gentile, F., De Angelis, F., De Vittorio, M., de la Prida, L. M., Valiente, M., Pisanello, F.. 2022-06-26. Deep brain cancer metastasis detection with wide-volume Raman spectroscopy through a single tapered fiber. https://doi.org/10.1101/2022.06.24.497456

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