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bioRxiv · 10.1101/2022.06.07.495238

Strongly bactericidal all-oral β-lactam combinations for the treatment of Mycobacterium abscessus lung disease

Negatu, D. A.·Zimmerman, M.·Dartois, V. A.·Dick, T.
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Abstract

Bioactive forms of oral {beta}-lactams were screened in vitro against Mycobacterium abscessus with and without the bioactive form of the oral {beta}-lactamase inhibitor avibactam-ARX1796. Sulopenem was equally active without avibactam, while tebipenem, cefuroxime and amoxicillin required avibactam for optimal activity. Systematic pairwise combination of the four {beta}-lactams revealed strong bactericidal synergy for each of sulopenem, tebipenem and cefuroxime combined with amoxicillin in the presence of avibactam. These all-oral {beta}-lactam combinations warrant clinical evaluation.

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Negatu, D. A., Zimmerman, M., Dartois, V. A., Dick, T.. 2022-06-08. Strongly bactericidal all-oral β-lactam combinations for the treatment of Mycobacterium abscessus lung disease. https://doi.org/10.1101/2022.06.07.495238

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