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bioRxiv · 10.1101/2022.06.05.494836

Trans-Radial Electrical Bioimpedance Velocimetry: A Novel Method for Detecting Cardiac Contractility

Stump, A.·Dundon, N. M.·Babenko, V.·Macy, A.·Grafton, S.
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Abstract

Increasing insight into the complex human response to external states can be captured by measuring event-related cardiac sympathetic activity. However existing assays are either confounded by influence from other branches of the autonomic system, or require preprocessing steps that eliminate moment-to-moment capture of fluctuation. We accordingly tested a novel device (TREV) that measures cardiac impedance directly from the radial and ulnar arteries of the human forearm, while healthy human participants performed a small number of trials of a task known to elicit sympathetic drive, a maximum-strength grip task. TREV recorded robust estimates of contractility at each heartbeat, that allowed fully automated beatwise estimations. TREV further reliably described credible group-level departures from baseline aligned with each individual grip in the task. We conclude that the device can be a useful addition to a broadening field exploring event-related sympathetic perturbations.

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Stump, A., Dundon, N. M., Babenko, V., Macy, A., Grafton, S.. 2022-06-06. Trans-Radial Electrical Bioimpedance Velocimetry: A Novel Method for Detecting Cardiac Contractility. https://doi.org/10.1101/2022.06.05.494836

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