REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?

Verma, A. K.; Lenis, S. F. A.; Aman, J. E.; Sanabria, D. E.; Wang, J.; Pearson, A.; Hill, M.; Patriat, R.; Schrock, L. E.; Cooper, S. E.; Park, M. C.; Harel, N.; Howell, M. J.; MacKinnon, C. D.; Vitek, J. L.; Johnson, L. A.

doi:10.1101/2022.05.25.493494

bioRxiv · 10.1101/2022.05.25.493494

REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?

Verma, A. K.·Lenis, S. F. A.·Aman, J. E.·Sanabria, D. E.·Wang, J.·Pearson, A.·Hill, M.·Patriat, R.·Schrock, L. E.·Cooper, S. E.·Park, M. C.·Harel, N.·Howell, M. J.·MacKinnon, C. D.·Vitek, J. L.·Johnson, L. A.

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Abstract

To elucidate the role of the basal ganglia during REM sleep movements in Parkinsons disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

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Verma, A. K., Lenis, S. F. A., Aman, J. E., Sanabria, D. E., Wang, J., Pearson, A., Hill, M., Patriat, R., Schrock, L. E., Cooper, S. E., Park, M. C., Harel, N., Howell, M. J., MacKinnon, C. D., Vitek, J. L., Johnson, L. A.. 2022-05-28. REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?. https://doi.org/10.1101/2022.05.25.493494

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