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bioRxiv · 10.1101/2022.05.16.492224

In-vivo detection of cyclic-di-AMP in Staphylococcus aureus

Chatterjee, S. S.·Mukkayyan, N.·Poon, R.·Sander, P.·Hammond, M.·Lai, L.-Y.·Zubair-Nizami, Z.
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Abstract

Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including antibiotic tolerance and osmoregulation in Staphylococcus aureus. In this study, we developed a novel biosensor (bsuO P6-4) for in-vivo detection of CDA in S. aureus. Our study showed that bsuO P6-4 could detect a wide concentration range of CDA in both laboratory and clinical strains making it suitable for use in both basic and clinical research applications.

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Chatterjee, S. S., Mukkayyan, N., Poon, R., Sander, P., Hammond, M., Lai, L.-Y., Zubair-Nizami, Z.. 2022-05-17. In-vivo detection of cyclic-di-AMP in Staphylococcus aureus. https://doi.org/10.1101/2022.05.16.492224

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