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bioRxiv · 10.1101/2022.05.10.491373

The statistical power of three monkeys

Abstract

Neuroscience studies in non-human primates (NHP) often follow the rule of thumb that results observed in one animal must be replicated in at least one other. However, we lack a statistical justification for this rule of thumb, or an analysis of whether including three or more animals is better than including two. Yet, a formal statistical framework for experiments with few subjects would be crucial for experimental design, ethical justification, and data analysis. Also, including three or four animals in a study creates the possibility that the results observed in one animal will differ from those observed in the others: we need a statistically justified rule to resolve such situations. Here, I present a statistical framework to address these issues. This framework assumes that conducting an experiment will produce a similar result for a large proportion of the population (termed representative), but will produce spurious results for a substantial proportion of animals (termed outliers); the fractions of representative and outliers animals being defined by a prior distribution. I propose a procedure in which experimenters collect results from M animals and accept results that are observed in at least N of them ( N-out-of-M procedure). I show how to compute the risks (of reaching an incorrect conclusion) and {beta} (of failing to reach a conclusion) for any prior distribution, and as a function of N and M. Strikingly, I find that the N-out-of-M model leads to a similar conclusion across a wide range of prior distributions: recordings from two animals lowers the risk and therefore ensures reliable result, but leaves a large risk {beta}; and recordings from three animals and accepting results observed in two of them strikes an efficient balance between acceptable risks and {beta}. This framework gives a formal justification for the rule of thumb of using at least two animals in NHP studies, suggests that recording from three animals when possible markedly improves statistical power, provides a statistical solution for situations where results are not consistent between all animals, and may apply to other types of studies involving few animals.

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BibTeXRIS

Laurens, J.. 2022-05-10. The statistical power of three monkeys. https://doi.org/10.1101/2022.05.10.491373

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