The modulation of acute stress on Model-Free and Model-Based reinforcement learning in Gambling Disorder

Wyckmans, F.; Banerjee, N.; Saeremans, M.; Otto, A. R.; Kornreich, C.; Vanderijst, L.; Gruson, D.; Carbone, V.; Bechara, A.; Buchanan, T.; Noel, X.

doi:10.1101/2022.05.05.490735

bioRxiv · 10.1101/2022.05.05.490735

The modulation of acute stress on Model-Free and Model-Based reinforcement learning in Gambling Disorder

Wyckmans, F.·Banerjee, N.·Saeremans, M.·Otto, A. R.·Kornreich, C.·Vanderijst, L.·Gruson, D.·Carbone, V.·Bechara, A.·Buchanan, T.·Noel, X.

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Abstract

Background and aimsExperiencing acute stress is common in behavioral addictions such as gambling disorder. Additionally, like most substance-induced addictions, aberrant decision-making wherein a reactive habit-induced response (conceptualized as a Model-free [MF] in reinforcement learning) suppresses a flexible goal-directed response (conceptualized as a Model-based [MB]) is also common in gambling disorder. In the current study we investigated the influence of acute stress on the balance between habitual response and the goal-directed system. MethodsA sample of N = 116 pathological gamblers (PG) and healthy controls (HC) performed an acute stress task - the Socially Evaluated Cold pressure task (SECPT) - or a control task. Self-reported stress and salivary cortisol were collected as measures of acute stress. Following the SECPT, participants performed the Two-Step Markov Task to account for the relative contribution of MB and MF strategies. Additionally, verbal working-memory and IQ measures were collected to account for their mediating effects on the orchestration between MB/MF and the impact of stress. ResultsBoth groups had comparable baseline and stress-induced cortisol response to the SECPT. Non-stressed PG displayed lower MB learning than HC. MANOVA and regression analyses showed a deleterious effect of stress-induced cortisol response on the orchestration between MB and MF learning in HC but not in PG. Neither working memory nor IQ mediated these effects. Discussion and ConclusionsDespite normal cortisol response to stress, we found an abnormal pattern of modulation of stress on the orchestration between MB and MF learning among PG.

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Wyckmans, F., Banerjee, N., Saeremans, M., Otto, A. R., Kornreich, C., Vanderijst, L., Gruson, D., Carbone, V., Bechara, A., Buchanan, T., Noel, X.. 2022-05-05. The modulation of acute stress on Model-Free and Model-Based reinforcement learning in Gambling Disorder. https://doi.org/10.1101/2022.05.05.490735

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