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bioRxiv · 10.1101/2022.05.04.490425

A marked enhancement of a BLOC-1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission

Seugnet, L.·Anaclet, C.·Perrier, M.·Ghersi-Egea, J.-F.·Lin, J.-S.
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Abstract

Histamine (HA) and orexin (Ox, or hypocretin) neurons act distinctly and synergistically in wake control. A double knock out mouse genotype lacking both HA and Ox shows all sleep disorders of human narcolepsy. We identified in this mouse brain a sharp upregulation of a BLOC-1 gene, pallidin that is associated with dramatic changes in the balance of cholinergic and aminergic systems in mice and an enhanced sleep in drosophila. This study demonstrates potential sleep disorders-associated compensatory mechanisms with pallid as a novel biomarker.

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Seugnet, L., Anaclet, C., Perrier, M., Ghersi-Egea, J.-F., Lin, J.-S.. 2022-05-05. A marked enhancement of a BLOC-1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission. https://doi.org/10.1101/2022.05.04.490425

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