Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis

Henry, I. M.; Comai, L.; Guo, W.

doi:10.1101/2022.04.27.489737

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bioRxiv · 10.1101/2022.04.27.489737

Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis

Henry, I. M.·Comai, L.·Guo, W.

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Abstract

Chromoanagenesis is a catastrophic event that involves localized chromosomal shattering and reorganization. In this study, we report a case of chromoanagenesis resulting from defective meiosis in the MEIOTIC ASYNAPTIC MUTANT 1 (asy1) background in Arabidopsis thaliana. We provide a detailed characterization of the genomic structure of this individual with a severely shattered segment of chromosome 1. We reveal more than 300 candidate novel DNA junctions in the affected region, confirming that asy1-related defective meiosis is a potential trigger for chromoanagenesis. This is the first example of chromoanagenesis associated with female meiosis and indicates the potential for genome evolution during oogenesis.

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Henry, I. M., Comai, L., Guo, W.. 2022-04-28. Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis. https://doi.org/10.1101/2022.04.27.489737

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